High throughput screening of human cancer samples using novel cancer-specific biomarkers for the development of digital patient stratification technologies based around the Axio Scan.Z1. (PhD Scholarship)

High throughput screening of human cancer samples using novel cancer-specific biomarkers for the development of digital patient stratification technologies based around the Axio Scan.Z1.

North West Cancer Research Institute, School of Medical Sciences, Bangor University.

Project ID: BUK2173
Annual Stipend: £14,198
Application Deadline: 16th September 2018

Project Description

The process of oncogenesis is associated with the activation of many genes. Some of these genes are normally only expressed in the germline and are silenced in healthy somatic tissue. A number of studies have demonstrated that germline gene activation contributes to cancer development and progression and can be linked to poor patient prognosis, so these genes have garnered interest as biomarkers and therapeutic targets.

The McFarlane Group has identified a number of novel germline genes that become activated and function in cancer progression and a new model for germline genes in oncogenesis has been put forward (McFarlane et al., 2014. Cell Cycle 13:2151-2152; McFarlane & Wakeman (2017) Cancer Research 77:5712-5716). This project will study the function of some of these genes and their utility as cancer biomarkers using high throughput instrumentation from Carl Zeiss Ltd. to assess a range of human cancer tissues.

Candidates will have a good first B.Sc. degree in an appropriate subject and must be a European Union citizen. Informal enquiries can be made to Dr. Ramsay McFarlane (r.macfarlane@bangor.ac.uk). The start date will be 1st November 2018.

How to apply:

Applications should include a covering letter and CV with two named referees. Please send via email to Dr Ramsay McFarlane  (r.macfarlane@bangor.ac.uk) and cc to Dr Penny Dowdney (p.j.dowdney@bangor.ac.uk) by 17:00 on 16/09/18.

Knowledge Economy Skills Scholarships (KESS 2) is a pan-Wales higher level skills initiative led by Bangor University on behalf of the HE sector in Wales. It is part funded by the Welsh Government’s European Social Fund (ESF) convergence programme for West Wales and the Valleys.

Due to ESF funding, eligibility restrictions apply to this scholarship. To be eligible, the successful candidate will need to be resident in the Convergence Area of Wales on University registration, and must have the right to work in the region on qualification.