Investigating stress specific functions of Mec1, the budding yeast functional homolog of the mammalian ATM/ATR
Location: School of Medical Sciences, NWCRI, Bangor University
Project ID: BUK2E015
Annual Stipend: £14483
Application Deadline: 28th February 2020
ATM and ATR are conserved signal transduction proteins involved in a range of fundamental processes including genome duplication, the DNA damage response (DDR), protein homeostasis, cellular metabolism, and meiosis. In humans, inactivation of ATM/ATR lead to a constellation of symptoms including neurodegeneration, cancer, diabetes, and growth retardation. While the mechanisms by which ATM/ATR proteins mediate the DDR are firmly established, the molecular basis underpinning the other functions remain poorly understood. This project will address the question utilising a powerful model organism S. cerevisiae and its ATM/ATR protein, Mec1. Specifically, the project will examine the mechanisms by which Mec1 senses and mediates cellular response to perturbation in protein homeostasis, utilising a combination of molecular biology, biochemistry, cytology and classical/large scale yeast genetic approaches.
Project supervisor: Dr Rita Cha
Start date: 1st. April 2020
Apply by 28th. February 2020
Please contact firstname.lastname@example.org for all enquiries.
How to apply :
Please send a CV and covering letter to Dr Rita Cha (email@example.com) and cc to Penny Dowdney (firstname.lastname@example.org).
KESS 2 East is a pan-Wales higher level skills initiative led by Bangor University on behalf of the HE sector in Wales. It is part funded by the Welsh Government’s European Social Fund (ESF) convergence programme for East Wales.
Due to ESF funding, eligibility restrictions apply to this scholarship. To be eligible, the successful candidate will need to be resident in East Wales on University registration, and must have the right to work in the region on qualification.